The office of the Deputy Prime Minister of the Kingdom of Yugoslavia was established on 26 August 1939, during the government of Dragiša Cvetković.

The office of the Deputy Prime Minister of SFR Yugoslavia was established on 2 February 1946, during the government of Josip Broz Tito.

Also, Deputy Prime Ministers sometimes combined the post with another government portfolio.

The office of the Deputy Prime Minister of FR Yugoslavia was abolished with the constitutional reforms of 2003.

Therefore, the last Deputy Prime Minister was Miroljub Labus, who served from 4 November 2000 to 17 March 2003.