Derhamia hoffmannorum is a species of freshwater fish endemic to Guyana, where it is found in the Mazaruni River.

[4] It is found in fresh water at pelagic depths [5] in a tropical climate.

They live near the surface of water and are known to hide whenever possible, usually under floating objects.

[4] The generic name honours Patrick de Rham, Swiss ichthyologist and aquarist (1936–2022), who collected the holotype specimens in the wild.

The specific epithet is in honor of Peter Hoffman and Martin Hoffman (Salzgitter and Hanover, Germany, respectively), who acclimated other specimens to captivity, giving authors additional information about its biology that could not have been known by studying them in the wild.