The program starred Sofia Milos, Michelle Belegrin, Nate Haden, Kelly Albanese, Zack Silva, Chuti Tiu, Jessie Ward, Tanisha Harper, Will Rolland, Al Bandiero, Kristen Kerr, and Eliana Alexander.

Along the way, the pair find themselves on a heated trail of passion, betrayal, and murder over the woman they both loved (played by Belegrin).

[1] The show first emerged in late 2005 as a September syndicated program for the stations on the FOX network to air in a weekend or midday time period.

After receiving lukewarm response from stations not owned and operated by Fox, Twentieth Television decided to pitch the show for June 2006 on the premise that teenagers are out of school and planted in front of their TV sets, and that reruns dominate network schedules.

Desire is based on the 2004 Colombian television program Mesa Para Tres (Table for Three), which aired on Caracol TV.

The U.K. Based trio All Mighty Whispers also have their song Heaven Have Me Now included in an episode of the series.

The Parents Television Council filed a complaint with the Federal Communications Commission, saying that the word "shit" was used in scripted dialogue during the September 21st broadcast.