The Desloge family, (/dəˈloʊʒ/)[1] centered mostly in Missouri and especially at St. Louis,[2] rose to wealth through international commerce, sugar refining, oil drilling, fur trading, mineral mining, saw milling, manufacturing, railroads, real estate, and riverboats.

The family has funded hospitals and donated large tracts of land for public parks and conservation.

In 1887, the land was cleared and company houses for his staff were constructed at the location which became known as Deslogetown: present-day Desloge, Missouri.

In 2011, Watlow, still a Desloge family business, employed 2,000 employees in 13 factories in the United States, Mexico, Europe, and Asia; had sales offices in 16 countries; and distributed globally.

[28] The family hosted Russian ballerinas, Shakespearean actors, King Hussein of Jordan, and Anne Morrow Lindbergh.

[30][31] In April 2024, the estate was sold to the Augustine Institute, a private Catholic graduate theology school, which announced plans to move there from Denver.

[36][37] Durie Malcolm, wife of Firmin V. Desloge IV, was long rumored to have been briefly married to John F. Kennedy in 1947 in Palm Beach, Florida.

[38][39][40][41][42] In 1998, Malcolm's sister-in-law, Mrs. William L. Desloge, endorsed the story in a personal interview: "Of course it's true, we were all there at the parties in Palm Beach with them.

[46] In 1955, Joseph Desloge donated to the state of Missouri some 2,400 acres of land acquired over 17 years in Reynolds County.