Desoto Acres is a census-designated place (CDP) in northwestern Sarasota County, Florida, United States.

It is 4 miles (6 km) north of downtown Sarasota and is bordered to the east by Desoto Lakes.

Desoto Acres was first listed as a CDP prior to the 2020 census.

It is part of the North Port-Bradenton-Sarasota, Florida Metropolitan Statistical Area.

This article about a location in Sarasota County, Florida is a stub.