The Despreux River is a tributary of the Harricana River, flowing into the municipalities of Eeyou Istchee Baie-James (municipality), in Jamésie, in the administrative region from Nord-du-Québec, in Quebec, in Canada.

The surface of the river is usually frozen from early November to mid-May, however, safe ice movement is generally from mid-November to the end of April.

The main hydrographic slopes near the Despreux River are: The Despreux River derives its source from a forest stream (elevation: 261 metres (856 ft)), located in the municipality of Eeyou Istchee James Bay (municipality).

The source of the Despreux River located at: From the source, the Despreux River flows over 44.7 kilometres (27.8 mi) according to the following segments: The Despreux River flows on the west bank of the Harricana River across the Island of Seven Mile, to: The toponym "Despreux River" was formalized on December 5, 1968, at the Commission de toponymie du Québec, when it was founded.

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