The Mannerelle River is a tributary of the Malouin River, flowing into the municipality of Eeyou Istchee Baie-James (municipality), in the administrative region of Nord-du-Québec, in Quebec, in Canada.

Its course crosses the cantons of Massicotte and Manthet.

The surface of the river is usually frozen from early November to mid-May, however, safe ice movement is generally from mid-November to the end of April.

The main hydrographic slopes near the Mannerelle River are: The Mannerelle River originates at the mouth of Manthet Lake (length: 2.6 kilometres (1.6 mi), elevation: 258 metres (846 ft)), in the southern part of the Eeyou Istchee James Bay (Municipality).

The source of the Mannerelle River is located at: From its source, the Mannerelle River flows more or less parallel to the Ontario border over 83.3 kilometres (51.8 mi) according to the following segments: The hydronym "Mannerelle River" was formalized on December 5, 1968, by the Commission de toponymie du Québec, at the creation of this commission.