Detlef Lohse (born 15 September 1963 in Hamburg) is a German physicist and professor in the University of Twente's Department of Physics of Fluids in the Netherlands.

He served as a postdoctoral research fellow at the University of Chicago with Leo Kadanoff from 1993 to 1995.

In 1997 he got his Habilitation in theoretical physics at the University of Marburg on the subject of Sonoluminescence.

[2] Lohse has been an external member of the Max Planck Institute for Dynamics and Self-Organization in Göttingen, Germany.

Since 2016, he is a founding member of the Max Planck Center for Complex Fluid Dynamics at University of Twente.