Missing only five games during his Patriots career, McCourty received two Pro Bowl selections and was also a member of three Super Bowl-winning teams.

[4] In 2007, McCourty and his twin brother Jason started at cornerback, with Devin compiling 63 tackles, two interceptions, one forced fumble, and three blocked kicks on special teams.

On March 10, 2010, McCourty attended Rutgers' annual pro day, but chose to stand on his combine numbers and only performed positional drills.

Head coach Bill Belichick named both McCourty and Darius Butler the starting cornerbacks to begin the regular season.

[23][24] He made his professional regular season debut and first career start in the Patriots' season-opener against the Cincinnati Bengals and recorded five solo tackles and a pass deflection in their 38–24 victory.

[26] On November 14, 2010, he collected a season-high 11 combined tackles (nine solo) and broke up a pass in the Patriots' 39–26 victory at the Pittsburgh Steelers in Week 10.

[29] On December 6, 2010, McCourty recorded three solo tackles, broke up a pass, and an interception as the Patriots routed the New York Jets 45–3 in Week 13.

[32] He finished his rookie season in 2010 with 82 combined tackles (69 solo), 17 pass deflections, seven interceptions, two forced fumbles, and a sack in 16 games and 16 starts.

[35][36] On January 16, 2011, McCourty started in his first career playoff game and collected three solo tackles in their 28–21 loss to the Jets in the AFC Divisional Round.

[38] Head coach Bill Belichick officially named McCourty the starter, alongside Leigh Bodden, to start the regular season.

[40] McCourty started in the Patriots' season-opener at the Miami Dolphins and collected a season-high 11 combined tackles (ten solo) and two pass deflections in their 38–24 victory.

[41] On November 13, 2011, he made four solo tackles during 37–16 victory at the Jets,[42] but exited in the second quarter after injuring his shoulder during a collision with teammate Sterling Moore.

[47][48] On February 5, 2012, McCourty started in Super Bowl XLVI and collected seven combined tackles as the Patriots lost to the New York Giants by a score of 21–17.

[59] McCourty immediately assumed the job as the starting free safety, replacing Patrick Chung, who was still recovering from a shoulder injury.

[60] On November 11, 2012, he made his debut as the starting free safety and recorded eight combined tackles, a pass deflection, and an interception in the Patriots' 37–31 win against the Bills in Week 10.

[61] McCourty finished the 2012 season with 82 combined tackles (63 solo), 13 pass deflections, five interceptions, two forced fumbles, and a touchdown in 16 games and 16 starts.

[64] On January 13, 2013, McCourty made his first postseason start at safety and collected eight combined tackles during a 41–28 win against the Houston Texans in the AFC Divisional Round.

In Week 2, McCourty deflected a pass and also returned an interception for a 60-yard gain before being pushed out of bounds at the goal line during a 30–7 win at the Minnesota Vikings.

[80] On February 1, 2015, McCourty collected five combined tackles and helped the Patriots defeat the Seattle Seahawks 28–24 and win Super Bowl XLIX.

On December 13, 2015, McCourty made one tackle before exiting the Patriots' 27–6 victory at the Texans in the second quarter due to an ankle injury.

[94] He started in the Patriots' season-opener at the Arizona Cardinals and recorded a season-high ten combined tackles (nine solo) in their 23–21 victory.

[104] On February 5, 2017, McCourty started in Super Bowl LI and made five combined tackles as the Patriots defeated the Atlanta Falcons 34–28 in overtime.

[108] McCourty finished the season with a career-high 97 combined tackles (80 solo), five pass deflections, an interception, and a sack in 16 games and 16 starts.

[112][113] On February 4, 2018, McCourty started in Super Bowl LII and collected seven combined tackles and two pass deflections in the Patriots' 41–33 loss to the Philadelphia Eagles.

[114] In the preseason, Devin McCourty was reunited with his brother Jason, who played as cornerback for the Titans from 2009 to 2016 and the winless Cleveland Browns in 2017.

[115] Jason started as the number two cornerback in New England's secondary and formed a strong duo with All-Pro corner Stephon Gilmore.

[130] In Week 14 against the Chiefs, McCourty forced a fumble on tight end Travis Kelce which was recovered by teammate Stephon Gilmore during the 23–16 loss.

[133] In Week 2 against the Seahawks on Sunday Night Football, McCourty recorded his first interception of the season off a pass thrown by Russell Wilson and returned it for a 43-yard touchdown during the 35–30 loss.

[134] In Week 13 against the Los Angeles Chargers, McCourty returned a field goal blocked by teammate Cody Davis for a 44-yard touchdown during the 45–0 win.

[148] Devin and Jason jointly delivered the 2019 commencement address at Rutgers; they also received honorary doctorates from their alma mater.