Didier Trono (born 1956) is a Swiss virologist and a professor at the École Polytechnique Fédérale de Lausanne (EPFL).

[12] Despite a longstanding interests in the biology of viruses and viral infections, research in Trono's lab at EPFL has shifted towards the study of mobile genetic elements called transposons and their role in the regulation of mammalian gene expression.

[13][14] In 2002, Trono was awarded the Leenaards Scientific Prize for his contributions to the understanding of the genetic factors of vulnerability towards HIV infections.

[16][17] Trono was awarded with two Advanced Grants from the European Research Council in 2010 and 2015 for projects on mammalian gene regulation by KRAB proteins and transposable elements.

He also received a Proof of Concept grant in 2016 for the development of a novel diagnostic method based on the analysis of transposable elements.