He spent the better part of his career with Sevilla, appearing in 159 competitive games over six La Liga seasons (16 goals) and winning two major titles.

Born in Moreno, Buenos Aires of Italian ancestry on his father's side,[5][6] Perotti joined Spain's Sevilla FC in the summer of 2007, from Club Deportivo Morón.

[7] At first he was assigned to the Andalusians' B team which had just won promotion to Segunda División, and proved instrumental as the side retained their league status.

[8][9][10] Perotti also started with the reserves in the 2008–09 season, receiving his first-team debut on 15 February 2009 as he appeared 15 minutes in a 2–0 win at RCD Espanyol.

[27] On 2 February 2022, Perotti returned to Italy and its top tier after signing a short-term contract with newly promoted US Salernitana 1919.

He made his debut five days later, playing the last ten minutes of the 2–1 friendly loss against Spain in Madrid after having come on as a substitute for FC Barcelona's Lionel Messi.