The team began the season competing in Serie A, the Coppa Italia, and the UEFA Champions League, but were knocked out in the round of 16 in the latter two competitions.

After a run of fourteen wins and three draws in their final seventeen matches, Roma managed to finish the league in third place, qualifying for the play-off round of the 2016–17 UEFA Champions League.

French coach Rudi Garcia began the season as Roma's manager for the third consecutive campaign, but was sacked on 13 January after a run of poor results.

[2] Former Roma coach Luciano Spalletti, who was at the club from 2005 to 2009, was hired to replace Garcia.

[3] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.