Diego César Santilli was born in the neighborhood of Palermo, Buenos Aires on April 6, 1967.

[3][4][5] He is coordinator of Asociación Buenos Aires en RED and, together with his wife, founder of CANI (Food Culture for an Intelligent, Responsible and Safe Nutrition).

In 2013, he was elected National Senator for the City of Buenos Aires; he was second in Republican Proposal's list, under Gabriela Michetti.

[6][7] Both Michetti and Santilli went on to leave the Senate to assume office in executive branches before the end of their term.

In 2021, he ran for a seat in the Chamber of Deputies in the Juntos por el Cambio list in Buenos Aires Province.