Don Diego de San Francisco Tehuetzquititzin (sometimes called Tehuetzquiti or Tehuetzqui) (died 1554) was the 16th tlatoani and second governor of Tenochtitlan.

According to Chimalpahin, Tehuetzquititzin's father Tezcatl Popocatzin was a son of Tizoc, the seventh ruler of Tenochtitlan.

In the same year, he participated in the Mixtón War in Nueva Galicia (Nahuatl: Xochipillan), led by viceroy Antonio de Mendoza.

[2] On 23 December 1546, a cédula was issued by Charles V and his mother Joanna granting don Diego a personal coat of arms in recognition of his service, particularly in the war in Nueva Galicia, and so that "other [Indian] nobles will be inspired to serve us".

He remained as juez until 1557, when don Cristóbal de Guzmán Cecetzin was installed as ruler.