[2][failed verification] Due to the low melting and boiling point, (−136.0 and −51.6 °C [−212.8 and −60.9 °F; 137.2 and 221.6 K] respectively) contact with this compound may result in frostbite.

Difluoromethane is primarily synthesized via batch processes, by the reaction of dichloromethane and hydrogen fluoride (HF), in the liquid phase using SbCl5 as a catalyst.

Difluoromethane is a molecule used as refrigerant that has prominent heat transfer and pressure drop performance, both in condensation and vaporization.

[9] Difluoromethane is thus a relatively low-risk choice among HFC refrigerants, most of which have higher GWP and longer persistence when leaks occur.

Volatilization half-lives of this compound are about 45 minutes for rivers and 69 hours for lakes, difluoromethane does not bioaccumulate in aquatic areas well.

Difluoromethane is excluded from the list of VOCs supplied in the United States Clean Air Act due to the ODP being zero.

[citation needed] Tropospheric ozone may lead to adverse health effects such as respiratory, cardiac or neurological damage.

[citation needed] Difluoromethane shows slight maternal and developmental toxicity at concentrations of approximately 50,000 ppm in rats, but not in rabbits.