Dihydropyridine calcium channel blockers

Dihydropyridine calcium channel blockers are derivatives of 1,4-dihydropyridine that are used as L-type calcium channel blockers.

[1] They are used in the treatment of hypertension.

[2] Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, the dihydropyridine calcium channel blockers lower blood pressure mainly by relaxing the smooth muscle of the blood vessel walls.

[3] Dihydropyridine class L-type calcium channel blockers include, in alphabetical order (brand names vary in different countries): The pharmaceutical drug finerenone is also a dihydrophyridine derivative, but does not act as a calcium channel blocker but as an antimineralocorticoid.

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