[1] Dimitrie was born in Ottoman Macedonia, as the son of Stoyan Mincho (Stogiannis Mintsos), a local chieftain.
Taking part in the Wallachian uprising of 1821, alongside fellow Serbian commander Hadži-Prodan,[5] he was appointed Tudor Vladimirescu's lieutenant by boyar allies of the revolutionaries, on January 15.
Sympathetic to the Philikí Etaireía and suspicious of Vladimirescu's level of commitment to the cause, Macedonski, together with Giorgakis Olympios and Iannis Pharmakis, deposed and arrested the rebel leader.
Macedonski was also involved in revolutionary agitation in 1840 Wallachia as a member of a radical conspiracy led by Mitică Filipescu and Nicolae Bălcescu.
On April 9, 1841, he was sentenced to eight years in prison, and held at the Snagov Monastery, where he fell ill with dropsy.