He joined the Filiki Eteria and became a revolutionary during the Greek War of Independence.

During the siege Dimitrios Makris married Eupraxia, daughter of the city's notable Samos Razi-Kotsikas.

[6] He later fought in Agrinio and Aitoliko and with the collaboration of Georgios Karaiskakis troops attacked and repulsed a body of Albanians.

After the establishment of the Greek kingdom Makris refrained from accepting any political and military honors.

Numerous weapons of Dimitros Makris are preserved in the City Hall of Missolonghi including the sword which he used in the Exodus of Missolonghi, which belonged to his ancestral family and dates back to the old fighters of 1732.