Dis-Chem is the second largest retail pharmacy chain in South Africa, with 165 stores, plus 4 in Namibia and 1 in Botswana.

Dis-Chem has private label products, sells via the Internet, operates a loyalty programme, and the Group has a wholesale division.

[3] Dis-Chem started in 1978 when pharmacists Ivan and Lynette Saltzman, opened their first retail pharmacy in Mondeor, a southern suburb of Johannesburg.

In 2014, Dis-Chem opened its first store outside South Africa, in Windhoek, Namibia.

[2] In July 2020, the Competition Commission of South Africa found Dis-Chem guilty of inflating prices of certain hygiene products (i.e. disposable face masks) during the COVID-19 pandemic.