A disulfiram-like drug is a drug that causes an adverse reaction to alcohol leading to nausea, vomiting, flushing, dizziness, throbbing headache, chest and abdominal discomfort, and general hangover-like symptoms among others.

[4] Drugs which cause disulfiram-like reactions upon ingestion of alcohol as an intended effect include:[5] Drugs which cause disulfiram-like reactions upon ingestion of alcohol as an unintended effect include:[6][1][7] A number of drugs do not cause disulfiram-like reactions, but have other unintended interactions with alcoholic drinks.

Patients on linezolid and tedizolid may be sensitive to the tyramine present in tap beers and red wine.

[8] Antibiotics such as metronidazole, tinidazole, cephamandole, latamoxef, cefoperazone, cefmenoxime, and furazolidone, cause a disulfiram-like chemical reaction with alcohol by inhibiting its breakdown by acetaldehyde dehydrogenase, which may result in vomiting, nausea, and shortness of breath.

[13] Natural compounds and species which have been found to cause disulfiram-like reactions upon ingestion of alcohol include:[14][15] Aldehyde dehydrogenase inhibitors may produce dopaminergic neurotoxicity or augment aging-related dopaminergic neurodegeneration by preventing the catabolism of the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL).