Division Street begins in the Gold Coast neighborhood near Lake Shore Drive, passes through Polonia Triangle at Milwaukee Avenue into Wicker Park and continues to Chicago's city limits and into the city's western suburbs.

Today, the street serves as the Near North Side's second major nightlife hub, second only to the upscale River North entertainment district, located north and east of the Chicago River, and west of the famed Michigan Avenue shopping district and south of Chicago Avenue, focusing on Hubbard Street as the epicenter.

Mother's is located in a basement, with many support pillars through its unusually-shaped space, due to the proximity of the tunnel for the Red Line train and its air intake shafts.

Farther west, around Damen Avenue (2000 W), are a number of upscale restaurants, shops, and bars.

[citation needed] In June 2024, the part of the Humboldt Park neighborhood in Chicago known as Puerto Rico Town or Paseo Boricua officially changed its name to Barrio Borikén.