During his undergraduate years, Nusinow worked in Jay Gralla's lab and studied in vitro analysis of RNA Pol II transcription in the fission yeast, S.pombe.
During his first four years of graduate school, Nusinow attempted to create a quadruple knock-in (KI) mouse that would purify the protein RNA complex of X-inactive specific transcript (Xist), which plays a key role in dosage compensation in female mammals.
In 2007, he became a researcher at the Scripps Institute with Steve Kay, and continued with the lab when it moved to University of California San Diego (UCSD) for five additional years.
Nusinow then became a principal investigator at the Donald Danforth Plant Science Center and an adjunct professor at Washington University in St. Louis in 2012.
[6] He now studies to understand how the circadian clock is integrated with environmental signals to control growth, development, and physiology in order to improve the productivity in plants.
[10] PhyB in turn forms photobodies in the nucleus, where it interacts with molecules of the evening complex (EC) to cause downstream inhibition of hypocotyl growth.
By stabilizing phyB and maintaining its signaling well into the night, PCH1 allows plant cells to “remember” past illumination and adjust growth programs accordingly.