Doe Run is an unincorporated community and census-designated place in St. Francois County, Missouri, United States.

[2] It is located on Routes 221 and B, approximately three miles southwest of Farmington.

[5] A post office called Doe Run has been in operation since 1887.

[6] The community takes its name from nearby Doe Run Creek.

This Saint Francois County, Missouri state location article is a stub.