The remote location of Dome Peak, combined with its height, make it a less common destination for Cascade Range mountaineers.

Dome Peak is at the southern end of the Ptarmigan Traverse mountaineering route.

Dana Glacier is on the north side of a ridge that connects Dome Peak and Spire Point.

The higher northeast peak was first climbed by George Freed and Eric Larson on August 1, 1936.

[3] The southwest peak was first climbed on July 5, 1936, by Forest Farr, Norval Grigg, and Don Blair.