Domingo Guzmán (born April 5, 1975) is a former Major League Baseball player.

He made his major league debut with the San Diego Padres in 1999, and played in 8 games from 1999 to 2000.

He traveled to Taiwan, and played one season in the Chinese Professional Baseball League with the Chinatrust Whales.

He set the world record for consecutive at-bat strikeouts with the BayStars, striking out 18 times in a row in 2003.

This biographical article relating to a Dominican Republic baseball pitcher is a stub.