Donald Guthrie, KC (May 8, 1840 – October 31, 1915) was a Scottish-born Ontario lawyer and political figure.

In 1863, he married Eliza Margaret daughter of John McVicar and Janet McTavish and a sister of Montreal Presbyterian minister Donald Harvey MacVicar.

He studied law with Oliver Mowat and Adam Johnston Fergusson Blair and was called to the Ontario bar in 1866; he was later named Queen's Counsel.

[2] He was first elected to the House of Commons in an 1876 by-election held when David Stirton was named postmaster for Guelph.

[1] Guthrie's former home later became part of the Homewood Sanitarium, the first psychiatric facility in Ontario.