Dong Ampham National Biodiversity Conservation Area is an extensive protected area which covers a significant part of Attapeu Province and Sekong Province in the southeast corner of Laos on the border with Vietnam.

It contains "some of the last intact areas of lowland and tropical forests remaining in mainland Southeast Asia.

[4] The wetlands are home to populations of Siamese crocodiles and Asian elephants, and large cats are known to inhabit the protected area.

[2] Large carnivores in the area include the sun bear (Helarctos malayanus), leopard cat (Panthera bengalensis), Asian golden cat (Catopuma temminickii), and clouded leopard (Neofelis nebulosa).

It is also home to the threatened primates red-shanked douc (Pygathrix nemaeus) and yellow-cheeked gibbon (Nomascus gabriellae).