The bridge was built in 1972, as part of a 1960s-era project to increase access to the industrial Monongahela Valley through a semi-freeway connection to Interstate 70.

However, the decline of the steel sector halted area road construction, and the entire project was not completed until 1989.

The road was originally named for former State Engineer C. Vance DeiCas.

[1] In 2011, a bill was introduced in the Pennsylvania House of Representatives to rename the structure for Baseball Hall of Fame member Stan Musial, a Donora native.

Effective January 8, 2012, Musial's name adorned the bridge.