It is narrowly endemic to Summit and Park Counties, Colorado, where several populations were estimated to total to approximately 300 individuals as of 2012.

D. weberi is principally threatened by alterations to its hydrologic environment, owing to its preference for wet, rocky streamside crevices.

[1] Draba weberi is a perennial herb which grows in small, dense tufts with pubescent stems 2 to 6 centimeters long.

Along with several other members of the genus Draba, D. weberi produces sterile pollen and reproduces asexually through agamospermy.

Consequently, its seeds are formed without fertilization and carry only maternal genes.