Driftwood is a small unincorporated community in northern Alfalfa County, Oklahoma, United States.

A formerly prosperous small rural community, at one time it had two churches, a grocery store, barber shop, gas station with repair shop, grain elevator, two-story school, a telephone office, bank, and post office.

Starting in 1874, the U Ranch headquarters was located a few miles north of present-day Cherokee, just southeast of Driftwood.

[6] In 1901, a stage line was established connecting nearby Kiowa, Kansas with Alfalfa county towns, including Burlington, Driftwood, Cherokee, Yewed, and Augusta.

[6][8] After the abandoning of its only rail line, the declining population had made it increasingly difficult to sustain educational and city services so that by 1980, Driftwood was no longer incorporated.