[2] Though primarily based around the original Duck Dodgers short (which is set in roughly 2318 AD), the series also takes visual and thematic cues from other Looney Tunes shorts, with other Looney Tunes characters appearing in the series, albeit adapted to fit within the show's universe.

[3] For example, Yosemite Sam becomes "K'chutha Sa'am", a parody of Klingons in Star Trek, Elmer Fudd becomes "The Fudd", a parasitic mind-altering alien disease, (a combination of the Flood and the Borg), Wile E. Coyote was a Predator-like alien hunter.

Also appearing in the show are Witch Hazel, Count Bloodcount, Goofy Gophers, Nasty Canasta, Taz, Rocky and Mugsy, the Crusher, "Shropshire Slasher", Michigan J. Frog, Ralph Phillips, Egghead Junior, and the unnamed evil scientist who owns Gossamer.

[8] After a prime time Daffy Duck series Brandt and Cervone were developing with Paul Rugg described as The Larry Sanders Show meets Jack Benny failed to emerge from development hell, Brandt and Cervone moved on to Duck Dodgers and incorporated some of their unused concepts.

[9] The Blu-ray set also includes the original 1953 short Duck Dodgers in the 24½th Century as a bonus feature.