It was created on 1503 by Apostolic authority of Pope Alexander VI and cardinal council over the ancient Marquissate of Camerino, which was part of the Dukedom of Spoleto.

Meanwhile, Cesar Borgia was in Rome making his final plans for his intervention in Tuscany, in Camerino the Lord of Faenza Manfredo Astorre, fidelity at Papal authority[clarification needed] is found floating in the Tiber, he had been strangled.

On 5 June Pope Alexander VI, excommunicated Giulio Cesare Varano, ruler of Camerino, accusing him of giving help to enemies of the church.

[4] Giovanni Borgia carried many other titles and he did after death of Alexander VI a career as ambassador.

On 1503 Pope returned Camerino to Juan Maria Varano in quality of Lord under Papal dukedom domine.