Having attended the program's youth summer camps for a decade,[2] McGuire committed to playing college soccer at Creighton University.

[3] With the 2020 season delayed until early 2021 because of the COVID-19 pandemic, McGuire eventually made his collegiate debut on February 20, 2021, away to Marquette Golden Eagles.

He was one of six players to appear in all 12 matches during the season, making four starts, scoring four goals and three assists, and was named to the All-Big East Second Team.

[5] Creighton also made a run to the NCAA College Cup semi-finals, losing to eventual champions Syracuse Orange 3–2.

[16] McGuire scored the equalizing goal against Houston Dynamo FC on July 21 in the group stage of the Leagues Cup, leading to a penalty shootout in which the Lions won.

[22] On January 31, 2024, McGuire flew to the United Kingdom to finalize a permanent transfer to EFL Championship side Blackburn Rovers.

[23] The following day it was announced Orlando City had reached an agreement with Blackburn Rovers for a six-month loan with an option to buy.

[24] The loan move was denied by the English Football League due to an "administrative error" during the submission of McGuire's registration documents by Blackburn Rovers, which meant the club missed the transfer deadline.

[27] In an interview later in May on Goal's Studs Up show, McGuire discussed the failed transfer to Blackburn Rovers and that he'd only be open to attempting to sign with the club again if they offered a very high paying contract.

[28] On February 21, McGuire scored the first goal for Orlando in their competitive 2024 season in a 3–0 victory over Cavalry FC in the first leg of their tie in the 2024 CONCACAF Champions Cup.

[35] After a failure to fix his shoulder on the sideline, it was relocated in the locker room and he was unable to participate in the penalty kick shootout.

McGuire started in their loss to France and win over New Zealand, but he came on as a 66th-minute substitute for Paxten Aaronson in their victory over Guinea, which secured the Americans moving onto the knockout stage in second place to face Morocco in the quarterfinals.