Dysgammaglobulinemia is a type of immune disorder characterized by a reduction in some types of gamma globulins, resulting in heightened susceptibility to some infectious diseases where primary immunity is antibody based.

[1] It is distinguished from hypogammaglobulinemia, which is a reduction in all types of gamma globulins.

[2] There are four main types of dysgammaglobulinemia.

[3] peripheral: Purine nucleoside phosphorylase deficiency