The E-ninnu 𒂍𒐐 (House of 50) was the E (temple) to the warrior god Ningirsu in the Sumerian city of Girsu in southern Mesopotamia.

The Gudea cylinders, perhaps the longest surviving text written in the Sumerian language, give a semi-mythical account of the building of the temple, along with a description of the rituals and symbols associated with E-ninnu.

More than a dozen diorite statues of Gudea were discovered, during French excavations at Girsu in the late 19th and early 20th centuries, in a Hellenistic-era shrine on the Mound of the Palais.

The Adadnadinakhe bricks show that shrine was built by a minor local king, Adad-Nadin-Akhe, to honour Gudea on the site of his temple to Ningirsu, which was then already 2000 years old.

[1] In February 2023, archaeologists from the British Museum and Getty Museum identified the E-ninnu temple alongside the remains of the 4,500 year-old Sumerian Lord Palace of the Kings and more than 200 cuneiform tablets containing administrative records of Girsu.