The EV6 traverses ten countries, from the mouth of the Loire eastward along that river to the Saône, across the border to Switzerland, along the Rhine to Lake Constance, north into Germany, down the Danube and through Austria, Slovakia, Hungary, Serbia, Croatia, Bulgaria, and Romania to the Danube Delta, before terminating at Constanța on the Black Sea.

It mostly runs along both sides of the Danube, which flows through diverse landscapes, including mountainous terrain, plains, and nature reserves as it passes through Germany, Austria, Slovakia, Hungary, Croatia, Serbia, Romania, and Bulgaria.

The route goes to Passau via Höchstädt, Donauwörth, Ingolstadt, the Weltenburg monastery, Kelheim, Regensburg, Straubing, Plattling and Vilshofen an der Donau.

Part IV of the path begins in Budapest and continues 1,670 km (1,040 mi) to the Black Sea in Romania.

In this section it passes through Hungary, Serbia, Bulgaria (where it passes the UNESCO Heritage site Srebarna Nature Reserve) then into Romania to the UNESCO Heritage site of the Danube Delta, before following the Black Sea coast to end at Constanța in Romania.