Lying within the Fall Line area of Georgia, the region borders South Carolina.

Among these counties, non-Hispanic whites and African Americans were the predominant racial and ethnic groups present in East Georgia, in common with the remainder of the state.

Religiously, East Georgia is within the Bible Belt, and Christianity has been the predominant religion since the colonial era.

East Georgia also had a substantial population of Jehovah's Witnesses and Mormons in the Church of Jesus Christ of Latter-day Saints according to the same study.

With an economy centered within the Augusta metropolis, its largest industries are medicine, biotechnology, cyber security, manufacturing, and education.