Mailing addresses associated with East Whiteland include Malvern, Frazer, and a small area of Exton.

Native Americans called the area "The Dark Valley" because of the numerous trees and undergrowth.

The Lapp Log House, St. Peter's Church in the Great Valley, Spring Mill Complex, and White Horse Tavern are listed on the National Register of Historic Places.

East Whiteland Township is located about 25 miles (40 km) west of Philadelphia.

Home to the Great Valley Corporate Center, the township also serves as U.S headquarters to several national and international firms including Siemens Health Services (formerly SMS), Vishay, SCT, Centocor and Aegon, as well as being home to numerous smaller businesses and retail shops.

U.S. Route 30 follows Lancaster Avenue along a southwest-northeast alignment through the southern portion of the township.

Pennsylvania Route 352 follows Sproul Road southeast from US 30 across the southern part of the township.

Finally, Pennsylvania Route 401 follows Conestoga Road northwest from US 30 through central and western portions of the township.

The former main line of the Pennsylvania Railroad, currently owned and operated by Amtrak and also used by SEPTA, passes through the township.

While no stations are located in the township, SEPTA Frazer Yard is a maintenance facility for the Paoli/Thorndale Line regional rail service.

In 2019, the Delaware Valley Regional Planning Commission conducted a feasibility study for a new SEPTA station in East Whiteland and recommended a location near Immaculata University.