It runs from just east of Parliament Street in the downtown to just west of Coxwell Avenue, near the Beaches neighbourhood.

Eastern was also home to the headquarters of the Toronto chapter of the Hells Angels, until it was raided and confiscated by police in April 2007.

Only with the demolition of Greenwood Racetrack was Eastern Avenue extended to flow directly into Kingston Road.

A small isolated section of Eastern Avenue runs from Sumach Street to Lawren Harris Square.

[5] A number of north-south buses use Eastern as the street they loop along before returning northwards.