[1] The origin of the district dates to 1964, when voters in all three sending communities approved a referendum to fund the construction of a high school.

In the 2015–16 season, the team beat Kingsway Regional High School in a series of 2–1 to claim the SJHSHL Tier 1-B Championship on a goal scored seven seconds into overtime.

[22] The wrestling team won the South Jersey Group III state sectional championships in 1983 and 1985[23] The softball team won the Group IV state championship in 1986 (against finalist Ridgewood High School) and 2012 (vs. Hunterdon Central Regional High School).

[24] The 1986 team finished the season with a 22-4 record after winning the Group IV title with 2-1 victory against Ridgewood in the championship game at Trenton State College.

[25] The team won the 2012 Group IV title with a 2–0 win in the finals against returning champion Hunterdon Central.

[26] The 1989 boys' basketball team won the Group III state championships, defeating runner-up Sparta High School by a score of 73-63 in the finals played at Fairleigh Dickinson University's Rothman Center[27][28] and came into the inaugural Tournament of Champions as the sixth seed, defeating third-seeded Haddonfield Memorial High School by a score of 56-54 in the quarterfinals before falling in the semis by 82-58 to number-two seed Elizabeth High School to finish the season with a record of 28-6.

[36] The football team won the NJSIAA South Jersey Group IV state sectional championship in 2003.

[40] In 2005, they won the Group IV South sectional championship over Toms River High School East 1–0.

[43] The baseball team won the Group IV state title in 2013 over runner-up Westfield High School.

[45] Eastern's field hockey team has the longest consecutive unbeaten streak in the history of the National Federation.

[50] The 2004 team repeated as Group IV champion, again defeating Hunterdon Central High School in the tournament final.

[51] In 2006, Eastern's field hockey team won the Tournament of Champions, defeating West Essex High School by a score of 2–1.

Eastern's dominance against New Jersey opponents finally came to an end on November 14, 2007, when they lost to Group I Oak Knoll 3–2 in overtime of the Tournament of Champions semifinals.

This 'Field Hockey Dynasty' was noted in an article in the Sunday edition of The New York Times, including profiles of team members.

Eastern conducts an award-winning theater program that includes an NJDFL Team Theatre (New Jersey State Champions 2008-09 and 2nd Place finishers in both 2011-12 and 2012–13), annual Fall Play and Spring Musical, and One-Acts Festival.

Eastern's 2010 musical, Chicago, earned Sarah Cheatham a Paper Mill Playhouse Rising Star nomination for her lead performance as 'Roxie.'