The Eastern Statistical Region (Macedonian: Источен Регион) is one of eight statistical regions of North Macedonia.

Eastern, located in the eastern part of the country, borders Bulgaria.

Internally, it borders the Vardar, Skopje, Northeastern, and Southeastern statistical regions.

Eastern statistical region is divided into 11 municipalities: The current population of the Eastern Statistical Region is 150,234 citizens or 8.2% of the total population of the Republic of North Macedonia, according to the last population census in 2021.

The largest ethnic group in the region are the Macedonians.