The Vardar Statistical Region (Macedonian: Вардарски Регион) is one of eight statistical regions of North Macedonia.

Vardar, located in the central part of North Macedonia, borders Greece to the south.

Internally, it borders the Pelagonia, Southwestern, Skopje, Southeastern, and Eastern.

The region is flatter than most of the rest of the country.

The largest ethnic group in the region is the Macedonians.