Piskor was known primarily for his work on Hip Hop Family Tree, X-Men: Grand Design, and the Red Room trilogy.

Piskor died on April 1, 2024, at the age of 41, hours after posting a suicide note via social media, defending himself against the allegations leveled against him.

Important influences included Harvey Kurtzman, Will Eisner, Jack Kirby, Robert Crumb, Daniel Clowes, Chris Ware, Kim Deitch,[2] Gilbert Shelton, and Frank Miller.

[4] Returning to Pittsburgh, Piskor established contact with other local area cartoonists, including Jim Rugg, Paulette Poullet, Pat Lewis, Tom Scioli, and Mark Zingarelli.

[3] In 2003, Piskor started collaborating with Jay Lynch on comics for Mineshaft, while working on his own minicomic Deviant Funnies, first published in 2004.

From 2008 to 2011, Piskor published Wizzywig, his own comic book series about a prodigy who becomes fascinated with social engineering, phone phreaking, and eventually computer hacking.

[15] In January 2024, Piskor started posting a daily comic strip online, Switchblade Shorties, which followed the (mis)adventures of five mischievous girls in the 1990s.

(The term "kayfabe" is generally to refer to the portrayal of staged events within the world of professional wrestling as real, including the presentation of competition, rivalries, and personas.

[17] One of the standout achievements of the series was bringing together Kevin Eastman and Peter Laird for commentaries[18] on their iconic Teenage Mutant Ninja Turtles comics.

In March 2024, cartoonist Molly Dwyer accused Piskor of engaging in inappropriate communication with her via social media in 2020 while she was 17 years old.

[26] In response to his accusers, he stated that the chats with Dwyer had been out of friendship and that the two times he had engaged in sexual intercourse with Wright were consensual and initiated by her.