[3] While at the camp, Keenan played on their military service football team under coach Percy Haughton.

[3] After receiving honorable discharge from the military, Keenan enrolled at Washington College in Chestertown, Maryland.

[6] A staff journalist for The Baltimore Sun wrote after the game, "That the Chestertown (Washington) line was able to hold the Green and Gold eleven (Western Maryland) while outweighed 20 pounds to the man was largely due to the efforts of big Eddie Keenan, who time after time piled up the plays directed at the center of the line.

[6] At the season's end, Keenan was named to the All-Maryland college football team by The Baltimore Sun.

"[7] At the end of the season he weighed 287 pounds, and was considered to be "one of the biggest men who ever played on a Maryland gridiron.

[10][11] In addition to playing guard, he was also sometimes used as a running back, making a 20-yard rush as well as several first down carries in the loss to St.

[11] At the end of the 1922 season, Keenan was again named to The Baltimore Sun All-Maryland squad as first-team selection.

[12] A report in the paper stated the following, "Keenan once again proved the mainstay of the Washington College forward combination.

[14] He played his fourth season of collegiate football in 1924, but was not selected to the All-Maryland team, although The Sun wrote that Keenan was one of those who "may be singled out from among the guards of the state for special mention.

"[15] A September 1924 article from The Evening Sun wrote the following, "There is something besides a joke in the playing of Ed Keenan, the big linesman.

"[16] Keenan played his final season of college football in 1925 and had reached 320 pounds in weight, but despite his size, was not "the slowest man in the world by any means.

[3] After college, Keenan signed with Red Grange's New York Yankees of the American Football League (AFL); however, he was among a group of players who quit the team early, because, as he later said, "we weren't getting enough [money] to take a train home.

[18] Keenan was officially signed by the Blues on September 14, and an article in the Hartford Courant wrote afterwards, "Hartford's professional Blues yesterday made room–plenty of room–for the largest man now playing football, Eddie Keenan the little 320 pound guard from Waterbury ... Eddie's arrival on the field without a uniform caused something of a riot and the soldiers went so far as to produce pup tents, all of which were too light for him ...

[20] He started the game as backup to Jack Bonadies, and later came in as a substitute for the latter, before being replaced by Ralph Nichols after playing for about 25 minutes.

"[21] In the Hartford practices held up to their regular season opener, Keenan played as the first-team guard.

[22] The regular season for Hartford began on September 26, as they faced the New York Giants in their first-ever game of NFL play.

[18] On the first play of the game, Giants guard Doc Alexander fumbled and Hartford recovered at the 30-yard line.

[18] It was the only high point for the Blues, as they failed a field goal attempt on their ensuing drive and finished the game without a single first down, as New York won 21–0.

[24][25] On October 8, an article ran in The Standard Union which said the following, "Two strange characters are carried by the Hartford Blues ... One is Eddie Keenan, of Waterbury, Conn., formerly in the line at Washington College, who weighs–and confesses to it–320 complete pounds.

[18] Keenan started at left guard in the game, a 16–6 win for Hartford which gave the Blues their first NFL victory.

[18] The amount of mud made the yard lines impossible to see and the players "quickly became anonymous" in dirty jerseys.

[33] Keenan started at right guard in the match, and was described as "showing special courage in struggling through to down carries although he always went under the heap, with his face shoved many inches into the mire.

[18] The Bulldogs bus left late and were caught in a traffic jam, only arriving at 3:00 p.m. 4,000 fans waited impatiently at the East Hartford Velodrome.

[18] Due to the late start, the inadequate lights at the stadium (which only effected the track around the playing field) had to be turned on in the fourth quarter.

[36] Despite the Blues cutting several veteran players prior to their matchup with the Triangles,[18] they won easily, 16–0, with Keenan starting at left guard.

[27] The Hartford Blues finished the 1926 season with three wins and seven losses in NFL play, placing 13th in the league rankings.

[27] Keenan was a starter at either right or left guard in every game,[2] and was said to have played "sturdy football" throughout the season for Hartford.

Eddie's huge bulk was not necessary in the style of play which Coach Dave Hayes is developing and as the Giants have three running tackles in Sullivan, Connelly and Ike Wooley.

[3] After each season, Keenan selected his own College Football All-America Team, based mostly on his evaluation of games he had seen.

[3] Keenan recalled his experiences in 1920s football through an interview with The Evening Sun in 1973, saying that the modern game "only slightly resembles what we played then.