The Preserve is owned and operated by The Nature Conservancy and Cincinnati Museum Center.

The area encompassing the Edge of Appalachia Preserve was first studied by ecologist Emma Lucy Braun in the 1920s.

The Edge of Appalachia Preserve is among the most biologically assorted areas in the Midwestern United States.

[2] The Edge of Appalachia Preserve contains 30 ecological communities, eight of which are classified as rare throughout the world.

The Edge of Appalachia Preserve is also home to the rare green salamander and Allegheny woodrat.