She earned a degree in English at the University of California Los Angeles (UCLA), and worked as a secretary before she married.
As a young wife and mother in the 1940s, Edith Wyle returned to painting, and studied with the painter and sculptor Rico Lebrun, who encouraged her particular interest in folk arts.
[2] In 1965, Edith Wyle opened The Egg and the Eye, a commercial gallery and café on Wilshire Boulevard, across from the La Brea Tar Pits and the Los Angeles County Museum of Art (LACMA).
[7] In connection with her museum work, Edith Wyle conceived of the Festival of Masks in 1976, a multicultural parade and arts celebration.
[1] The Edith R. Wyle Research Library of the Craft and Folk Art Museum, now housed at LACMA, was named in her honor in 1995.