It still operates laboratories, but its primary business focus is on securing long term services contracts from the Department of Defense, NASA and other Federal agencies.

In 1998, Wyle acquired Krug Life Sciences, an aero-medical research company with 30-plus years of history supporting NASA's crewed space flight programs.

In January 2005, Wyle acquired the General Dynamics Aeronautics division, formerly a part of Veridian, adding aviation research, development, test and evaluation (RDT&E) expertise to the company's portfolio.

In May 2009, Wyle entered into a merger agreement to be acquired by Court Square Capital Partners, an investment company which is now the majority shareholder.

In 2003, Wyle signed an order with the state California Department of Toxic Substances Control agreeing to find and clean up all contamination from the site.

[6] The Norco High School property, adjacent to the former lab, tested positive for trichloroethylene at 61 micrograms per liter in a California Department of Toxic Substance Control report from August 16, 2005.