Served by Via Rail's The Canadian, the station is unusually located on a branch off the main line, meaning that trains must either reverse into or out.

Edmonton station lies directly south of the Yellowhead Trail at 12360 121 Street NW, east of the neighbourhood of Prince Charles.

The closest hotels are located more than a kilometre to the south on Kingsway NW near the site of the former City Centre Airport.

The City Centre Campus of Grant MacEwan University lies on what was once CN railyards to the west of the former station.

[2] Greyhound operated a shuttle bus for their passengers with tickets, to deal with the lack of public transit to the station.