Later, he moved into a practice in Geneva, where he met his future wife, Lucrece, and there, with the exception of a period spent in North Africa, he made his home for the rest of his life.

Wyss-Dunant also participated in several expeditions further afield: in Mexico (1936), East Africa (1937), Greenland (1938), Tibesti (Chad) (1946) and in the Himalaya (1947 and 1952).

Wyss-Dunant also served as president of the Swiss Alpine Club and the Union Internationale des Associations d'Alpinisme.

[3] The mountaineering task that this team had set itself was primarily exploring the access to the South Col, the conquest of the labyrinthine Khumbu Icefall, and possibly the advance to the South Col. Raymond Lambert and Sherpa Tenzing Norgay were able to reach a height of about 8,595 metres (28,199 ft) on the southeast ridge, setting a new climbing altitude record.

At the first attempt, they had opened up a new route to Everest, and had reached an extraordinary height on the south-western ridge in difficult conditions.