He was married to Isabella Montagu, Dowager Duchess of Manchester, a rich heiress.

Edward was born in 1721, the son of James Hussey and his wife Catherine Parsons.

The senior branch of the family held the title Baron Galtrim, although this appears to have been an Irish feudal barony rather than a peerage and did not entitle its holder to sit in the Irish House of Lords.

In 1743, Hussey married Isabella Montagu, Dowager Duchess of Manchester, a rich heiress, first daughter and co-heiress of the 2nd Duke of Montagu and Lady Mary née Churchill (a daughter of the 1st Duke of Marlborough).

[5] Hussey had one child from Martha Howel, a housemaid in the service of Lord Beaulieu: From 1758 to 1762, he was Member of Parliament for Tiverton and a Whig.